Q7K740 · 3D7 · 397 aa
N-terminusJunctionalRepeatC-terminus
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| Antibody | Region | Epitope observed | Footprint | VH germline | Isotype | KD | IC50 | PDB |
|---|---|---|---|---|---|---|---|---|
| 1061 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| 1210 Homo sapiens · wild-type | Repeat· major | ANPNANPNANPNANPNANP | repeat frame | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| 1392 Homo sapiens · wild-type | C-terminus | EPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEKC | 314-314, 317-321, 324-334, 343-343, 346-346, 350-360, 369-371 | IGHV4-4*07 | TBU | TBU | TBU | 1 |
| 1393 Homo sapiens · wild-type | C-terminus | - | repeat frame | - | TBU | TBU | TBU | 1 |
| 1437 Homo sapiens · wild-type | C-terminus | - | repeat frame | - | TBU | TBU | TBU | 1 |
| 1450 Homo sapiens · wild-type | Repeat· major | NANPNANPNANPNANPNAN | repeat frame | IGHV3-23*01 | TBU | TBU | TBU | 1 |
| 1488 Homo sapiens · wild-type | C-terminus | EPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEKCS | 313-324, 327-327, 330-340, 343-347, 351-367, 370-375 | IGHV3-21*01 | TBU | TBU | TBU | 1 |
| 1502 Homo sapiens · wild-type | C-terminus | - | repeat frame | - | TBU | TBU | TBU | 1 |
| 1504 Homo sapiens · wild-type | C-terminus | - | repeat frame | - | TBU | TBU | TBU | 1 |
| 1512 Homo sapiens · wild-type | C-terminus | EEPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEK | 309-318, 321-322, 325-325, 331-331, 338-352, 355-356, 360-362, 365-370 | IGHV3-30*01 | TBU | TBU | TBU | 1 |
| 1525 Homo sapiens · wild-type | C-terminus | - | repeat frame | - | TBU | TBU | TBU | 1 |
| 1534 Homo sapiens · wild-type | C-terminus | - | repeat frame | - | TBU | TBU | TBU | 1 |
| 1550 Homo sapiens · wild-type | C-terminus | - | repeat frame | - | TBU | TBU | TBU | 1 |
| 1710 Homo sapiens · wild-type | C-terminus | EPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEKC | 314-321, 324-324, 327-330, 338-340, 347-364, 374-374 | IGHV3-21*01 | TBU | TBU | TBU | 1 +1 apo |
| 224 (anti-NANP) Homo sapiens · wild-type | Repeat· major | NPNANPNANPNA | repeat frame | IGHV3-49*04 | TBU | TBU | TBU | 1 +2 apo |
| 2243 Homo sapiens · wild-type | Repeat· major | NPNANPNANPNANPNANP | repeat frame | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| 227 Homo sapiens · wild-type | Repeat· major | NPNANPNANPNANPNANPNANPNANPNANPNA | repeat frame | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| 234 Homo sapiens · wild-type | C-terminus | EPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEK | 310-310, 314-314, 317-321, 324-327, 331-331, 340-340, 345-348, 354-361, 364-370 | IGHV3-21*08 | TBU | TBU | TBU | 1 |
| 236 Homo sapiens · wild-type | C-terminus | PSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKME | 314-314, 317-333, 337-337, 343-345, 348-350, 353-360, 370-371 | IGHV3-48*01 | TBU | TBU | TBU | 1 |
| 239 Homo sapiens · wild-type | Repeat· major | DPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNA | 111-190 | IGHV3-33*03 | TBU | TBU | TBU | 3 |
| 2541 Homo sapiens · wild-type | Repeat· major | NPNANPNANPNANPNAN | repeat frame | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| 2A10 Mus musculus · wild-type | Repeat· major | No structure | repeat frame | No structure | TBU | TBU | TBU | - +2 apo |
| 2D4 Mus musculus · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| 311 Homo sapiens · wild-type | Repeat· major | DPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANP | 103-191 | IGHV3-33*01 | TBU | TBU | TBU | 4 |
| 311R Homo sapiens · point-variant | Repeat· major | ANPNANPNAN | repeat frame | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| 317 Homo sapiens · wild-type | Repeat· major | NPNANPNANPNA | repeat frame | IGHV3-30*01 | TBU | TBU | TBU | 1 |
| 3246 Homo sapiens · wild-type | Repeat | VDENANANSA | 293-301 | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| 334 Homo sapiens · wild-type | Repeat· major | DPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNA | 119-190 | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| 337 Homo sapiens · wild-type | Repeat· major | NPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNA | repeat frame | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| 352 Homo sapiens · wild-type | C-terminus | PSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKM | 313-314, 317-321, 324-324, 327-327, 331-333, 337-337, 343-343, 353-362, 370-371 | IGHV3-21*08 | TBU | TBU | TBU | 1 |
| 356 Homo sapiens · wild-type | Repeat· major | DPNANPNVDPNANPNVDPNANPNVDPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNA | 103-190 | IGHV3-33*01 | TBU | TBU | TBU | 2 |
| 364 Homo sapiens · wild-type | Repeat· major | NPNANPNANPNANPNANPNANPNANPNANPNANPNANPNA | repeat frame | IGHV3-33*03 | TBU | TBU | TBU | 2 |
| 366 Homo sapiens · wild-type | Repeat· major | NPNANPNANPN | repeat frame | IGHV1-2*02 | TBU | TBU | TBU | 1 |
| 367 Homo sapiens · wild-type | C-terminus | - | repeat frame | - | TBU | TBU | TBU | 1 |
| 369 Homo sapiens · wild-type | C-terminus | - | repeat frame | - | TBU | TBU | TBU | 1 |
| 3764 Homo sapiens · wild-type | C-terminus | NMPNDPNRNV | 285-293 | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| 389 Homo sapiens · wild-type | C-terminus | - | repeat frame | - | TBU | TBU | TBU | 1 |
| 3945 Homo sapiens · wild-type | Repeat· major | ANPNANPNANP | repeat frame | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| 395 Homo sapiens · wild-type | Repeat· major | NPNANP | repeat frame | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| 397 Homo sapiens · wild-type | Repeat· major | NPNANPNANPN | repeat frame | IGHV3-15*01 | TBU | TBU | TBU | 1 |
| 399 Homo sapiens · wild-type | Repeat· major | NPNANPNANPNANPNANPNANPNA | repeat frame | IGHV3-49*03 | TBU | TBU | TBU | 2 +1 apo |
| 3C1 Mus musculus · wild-type | Repeat· major | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| 3C2 Mus musculus · wild-type | Repeat· major | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| 3D3 Mus musculus · wild-type | Repeat· major | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| 4C1 Mus musculus · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| 4C6 Mus musculus · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| 580 Homo sapiens · wild-type | Repeat· major | No structure | repeat frame | No structure | TBU | TBU | TBU | - +1 apo |
| 580 germline Homo sapiens · germline-reverted | Repeat· major | ANPNANPN | repeat frame | IGHV3-23*01 | TBU | TBU | TBU | 1 |
| 5D5 Mus musculus · wild-type | N-terminus | EDNEKLRKPKHK | 81-92 | IGHV1-81*01 | TBU | TBU | TBU | 1 |
| 663 Homo sapiens · wild-type | Repeat· major | ANPNANP | repeat frame | IGHV3-23*03 | TBU | TBU | TBU | 1 +1 apo |
| 663 germline Homo sapiens · germline-reverted | Repeat· major | No structure | repeat frame | No structure | TBU | TBU | TBU | - +1 apo |
| 667 Homo sapiens · wild-type | Repeat· major | NPNANPNA | repeat frame | IGHV1-3*01 | TBU | TBU | TBU | 1 |
| 668 Homo sapiens · wild-type | Junctional | GNPDPNANP | 101-108 | IGHV1-3*01 | TBU | TBU | TBU | 1 |
| 850 Homo sapiens (human-Ig transgenic mouse) · wild-type | Repeat· major | PNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNANPNA | 156-195, 200-270 | IGHV3-33*03 | TBU | TBU | TBU | 2 +1 apo |
| CIS23 Homo sapiens · wild-type | Repeat· major+minor | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| CIS34 Homo sapiens · wild-type | Repeat | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| H.2140/K.1210 chimera Homo sapiens · chimera | Repeat· major | NANPNANPNAN | repeat frame | IGHV3-33*03 | TBU | TBU | TBU | 1 |
| Ky15.1 Mus musculus · wild-type | Junctional | DGNPDPNAN | 99-106 | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| Ky15.10-Y100E/K variant Mus musculus · point-variant | Junctional | PDPNANPN | 102-109 | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| Ky15.11-S100I/K variant Mus musculus · point-variant | Junctional | NPDPNANPN | 101-109 | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| Ky230 Mus musculus · wild-type | Repeat· major | PNANPNANPNA | repeat frame | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| Ky311 Mus musculus · wild-type | Junctional | DGNPDPNAN | 99-106 | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| L15 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| L20 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| L37 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| L4 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| L40 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| L7 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| MA6 Homo sapiens · wild-type | Repeat· major | NPNANPNAN | repeat frame | IGHV3-33*01 | TBU | TBU | TBU | 1 |
| mAb04 (mAb4) Homo sapiens · wild-type | Repeat· major | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| mAb09 Homo sapiens · wild-type | Repeat· major+minor | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| mAb10 Homo sapiens · wild-type | Repeat· major | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| mAb15 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| MAD2-6 (IgA/IgG Fab) Homo sapiens · wild-type | N-terminus | LRKPKHKKLKQ | 86-96 | IGHV4-39*01 | TBU | TBU | TBU | 2 |
| MAD21-101 Homo sapiens · wild-type | N-terminus | EPADGNPDPNANPNVDPN | 84-84, 97-112, 397-397 | IGHV4-59*02 | TBU | TBU | TBU | 1 |
| MAD22-38 Homo sapiens · wild-type | N-terminus | EPADGNPD | 84-84, 97-101 | IGHV4-39*01 | TBU | TBU | TBU | 1 |
| MAD24-01 Homo sapiens · wild-type | N-terminus | EPADGNPD | 84-84, 97-103 | IGHV3-11*05 | TBU | TBU | TBU | 1 |
| MGG8 Homo sapiens · wild-type | Repeat· major | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| MGH1 Homo sapiens · wild-type | Repeat· major | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| MGH3 Homo sapiens · wild-type | Repeat· major | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| MGU1 Homo sapiens · wild-type | Repeat· major+minor | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| R1 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| R2 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| R3 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| R4 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| R7 Homo sapiens · wild-type | C-terminus | No structure | repeat frame | No structure | TBU | TBU | TBU | - |
| sdAb1 Lama glama · wild-type | C-terminus | PSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEKCS | 313-314, 317-333, 337-337, 345-345, 351-352, 355-361, 370-373 | IGHV3-23*01 | TBU | TBU | TBU | 1 |
| sdAb9 Lama glama · wild-type | C-terminus | EPSDKHIKEYLNKIQNSLSTEWSPCSVTCGNGIQVRIKPGSANKPKDELDYANDIEKKICKMEKCSS | 310-310, 313-314, 317-321, 324-326, 331-331, 337-340, 345-345, 351-370, 373-376 | IGHV3-23*01 | TBU | TBU | TBU | 1 |